While there may be an association, it is not clear that an overactive thyroid actually causes breast cancer to develop. The authors report no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. As radioactive iodine RAI treatment may synthroid and estrogen positive breast cancer breast cancer risk 27we conducted a sensitivity analysis in which follow-up was censored at initiation of RAI treatment. The role of treatment should be explored in further studies. Breast cancer is the most commonly diagnosed cancer among women in the United States, and thyroid disorders affect millions of American women.
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Hypothyroidism and hyperthyroidism and breast cancer risk: a nationwide cohort study
In contrast to the experimental evidence that T 3 and estrogen synergistically stimulate certain breast cancer cell lines 34632in our study, the association between hyperthyroidism and breast cancer risk was not modified by ER status. While this study might lead some to conclude that having excess thyroid hormone promotes the development of breast cancer, experts caution that this study does not prove cause and effect. In vitrohigh levels of thyroid hormones have estrogen-like effects 34promoting breast cancer cell proliferation 56 and stimulating angiogenesis 7.
The hyperthyroidism-associated increased risk persisted beyond 5 years of follow-up SIR: However, a sensitivity analysis restricted to patients diagnosed from onward and stratified by inpatient vs outpatient diagnoses, yielded similar findings. The corresponding percentages for hyperthyroidism were
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